High-affinity choline uptake protein bett

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August undefined, 2024

Webmax of 80 nmol/min/mg of protein) for choline transport relative to other known BCCTs. Although BetT activity increased in response to hyperosmolarity, BetT mediated signiﬁcant uptake under low ... WebIn addition to the industrial and biomedical applications of lithium, information on the tolerance of microorganisms to high Li concentrations in natural biological systems is limited. Strain LCHXa is a novel free-living Gram-positive, non-motile

CHT1 (High-affinity Choline Transporter) SpringerLink

Web1 de jan. de 2024 · CHT1 has been functionally characterized by its capacity to transport choline with high affinity when expressed in cultured cells or Xenopus oocytes. CHT1 transports choline with a Km value of 1–5 μM in a Na + - and Cl −-dependent manner (Okuda et al. 2000).The only known specific inhibitor of CHT1 is hemicholinium-3 (HC-3), … Webactivity increased in response to hyperosmolarity, BetT mediated signiﬁcant uptake under low-osmolarity conditions, suggesting a role in transport for both osmoprotection … describe intent for the query spanish

Identification and Characterization of the High-Affinity Choline ...

WebMeyer EM, Cooper JR (1983) High affinity choline uptake and calcium-dependent acetylcholine release in proteoliposomes derived from rat cortical synaptosomes. J … WebThe initial step in the CDP-choline/Kennedy pathway is uptake of choline into cells by three classes of transporters: the high-affinity (K D 2 μM), sodium-coupled choline transporter 1 (CHT1 or SLC5A7); intermediate-affinity (K D 10–100 μM), sodium-independent choline transporter-like (CTL) proteins of the SLC44A family; and low … Web23 de dez. de 2009 · We identified a choline, betaine and carnitine transporter, designated Cbc, from Pseudomonas syringae and Pseudomonas aeruginosa that is unusual among members of the ATP-binding cassette (ABC) transporter family in its use of multiple periplasmic substrate-binding proteins (SBPs) that are highly specific for their … chrysler table

Competitive inhibition of the high-affinity choline transporter by ...

Pseudomonas syringae BetT is a low-affinity choline ... - PubMed

WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … describe intervention if applicableWebE. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA … describe internal energy thermal

"WebThe uptake of choline can occur via two transport systems, one that exhibits a high affinity for choline uptake (HAChU, K m =1–5 μM) and is dependent on both Na + and Cl −, and a second transporter system that has a significantly lower affinity for choline uptake (LAChU, K m =10–100 μM) and is independent of Na + and Cl − (see also Ch. 3). " - High-affinity choline uptake protein bett

High-affinity choline uptake protein bett

WebStaphylococcus aureus; pan ID: SAUPAN006318000; symbol: cudT; products: choline transporter BetT, choline transporter, BCCT family choline/carnitine/betaine … WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. …

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WebCholine uptake (Vmax) increases up to 3 months of age and decreases significantly from 1 to 7 years of age ( Fig. 6A; Table III ). A further indication of a reduced synthesis with … WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules)

WebHigh affinity choline uptake is generally believed to be the rate-limiting step in acetylcholine synthesis in cholinergic neurons and is essential for cholinergic ... hCHT1 protein is composed of 580 amino acids with a predicted molecular mass of 63 kDa. Sequence analysis of the hCHT1 protein predicts 13 transmembrane domains (13, 20, 21). WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules)

Web31 de out. de 2000 · Na +-dependent, high-affinity choline uptake in cholinergic neurons is the rate-limiting step in acetylcholine synthesis.Here we report the molecular cloning and functional characterization of the human high-affinity choline transporter (hCHT1). The hCHT1 exhibits significant homology with known members of the Na +-dependent … WebCholine uptake is regulated by nerve impulses and trafficking of an intracellular pool of CHT1 to the plasma membrane may be important for this regulation. We have generated a hemagglutinin (HA) epitope tagged CHT1 to investigate the organelles involved with intracellular trafficking of this protein. Expression of CHT1-HA in HEK 293 cells ...

Web1 de mar. de 2007 · For osmoprotection, Escherichia coli can synthesize glycine betaine from externally supplied choline by the Bet system (betTIBA products). The major carrier of choline is the high-affinity, proton-driven, secondary transporter BetT, which belongs to the BCCT family of transporters. Fusion proteins consisting of N-terminal fragments of …

WebCHT1 protein is mainly found in intracellular organelles, such as endosomal compartments and synaptic vesicles. The presence of CHT1 at the plasma membrane is limited by … chrysler tagoraWebCholine uptake High affinity Na+-dependent Synaptosomes Certain basic characteristics of choline uptake in nerve terminals were ... protein, 0,567 uM [3H]-choline (final concentration), for 20 min at 371. The KM value of [3H]-choline uptake was 2.27+0.26 10 20 30 40 Time (min) 60 B I chrysler tahoeWebThe nature of the high affinity uptake system guarantees that cholinergic cells will always receive priority access to all available choline. Because of this, choline will be … chrysler taglineWebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity … chrysler tahoe suvWebA molecular phylogenetic analysis of salt-tolerance-related genes was carried out using complete genome sequencing data available for 26 Sinorhizobium meliloti strains and for 25 bacterial strains belonging to 17 genera. It was revealed that the genes of the first and the second stages of the response to salt stress (aqpZ, trkH, and trkA, and betICBA) have … describe israel\\u0027s god yahweh three adjectivesWeb8 de mar. de 2006 · The high-affinity choline transporter at the molecular level. Despite the fact that the high-affinity choline uptake system was described in the 1960s, the genes … describe in your own wordsWeb29 de mar. de 2024 · This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from … describe is rosellini waterman and mccunn